EFFECT OF ASIATIC MANGROVE (RHIZOPHORA MICRONATA) LEAVES EXTRACT AS ANALGESIC IN MALE ALBINO DDW MICE (MUS MUSCULUS L.) INDUCED BY 0,7% ACETIC ACID

Background : Pain is an unpleasant emotional experience that illustrates ongoing tissue damage. Excessive use of non-steroidal anti-inflammatory drugs can cause peptic ulcer to gastric mucosal damage and perforation. Indonesia contains the largest area mangrove forest in world. There are 45 species found one them Asiatic Mangrove (Rhizophora mucronata). This type easy find rich alkaloids flavonoids which be used as analgesics. Method: study post-test only control group design. The number mice was 25 mice, divided into 5 groups. Which were given different therapies aquadest 10mL/KgBW, acetosal 150 mg/KgBW, extract Rhizophora mucronata 250 500 1000 mg/kg bw. pain induced by 0,7% glacial acetic acid at a dose 10 mL/KgBW. writhes being calculated with interval minutes 30 minutes. Result: results analysis showed decrease bw, leaves significant difference Mann-Whitney U test p<0,05 between bw Conclusion: provide analgesic effect reduce writhing frequency much better than group.